磯 達也

原著論文

Tanaka T, Nishimura D, Wu RC, Amano M, Iso T, Kedes L, Nishida H, Kaibuchi K, Hamamori Y. Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. J Biol Chem. 2006;281(22):15320-9.

Niwano K, Arai M, Koitabashi N, Hara S, Watanabe A, Sekiguchi K, Tanaka T, Iso T, Kurabayashi M. Competitive binding of CREB and ATF2 to cAMP/ATF responsive element regulates eNOS gene expression in endothelial cells. Arterioscler Thromb Vasc Biol. 2006;26(5):1036-42.

Iso T, Maeno T, Oike Y, Yamazaki M, Doi H, Arai M, Kurabayashi M.  Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells.Biochem Biophys Res Commun. 2006;341(3):708-14.

Sato H, Sato M, Kanai H, Uchiyama T, Iso T, Ohyama Y, Sakamoto H, Tamura J, Nagai R, Kurabayashi M. Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells. Cardiovasc Res. 2005;67:714-722.

Doi H, Iso T, Yamazaki M, Akiyama H, Kanai H, Sato H, Kawai-Kowase K, Tanaka T, Maeno T, Okamoto EI, Arai M, Kedes L, Kurabayashi M. HERP1 Inhibits Myocardin-Induced Vascular Smooth Muscle Cell Differentiation by Interfering With SRF Binding to CArG Box. Arterioscler Thromb Vasc Biol. 2005;25:2328-2334.

Sato M, Tanaka T, Maemura K, Uchiyama T, Sato H, Maeno T, Suga T, Iso T, Ohyama Y, Arai M, Tamura J, Sakamoto H, Nagai R, Kurabayashi M. The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am J Respir Cell Mol Biol. 2004;31:209-215.

Okumura W, Iwasaki T, Toyama T, Iso T, Arai M, Oriuchi N, Endo K, Yokoyama T, Suzuki T, Kurabayashi M. Usefulness of fasting 18F-FDG PET in identification of cardiac sarcoidosis. J Nucl Med. 2004 Dec;45(12):1989-98.

Oyama Y, Kawai-Kowase K, Sekiguchi K, Sato M, Sato H, Yamazaki M, Ohyama Y, Aihara Y, Iso T, Okamaoto E, Nagai R, Kurabayashi M. Homeobox protein Hex facilitates serum responsive factor-mediated activation of the SM22alpha gene transcription in embryonic fibroblasts. Arterioscler Thromb Vasc Biol. 2004;24:1602-7.

Sato M, Tanaka T, Maemura K, Uchiyama T, Sato H, Maeno T, Suga T, Iso T, Ohyama Y, Arai M, Tamura J, Sakamoto H, Nagai R, Kurabayashi M. The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am J Respir Cell Mol Biol. 2004 ;31:209-15.

Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, Iso T, Dotto GP, Hamamori Y, Kedes L, Kato M, Dijke Pt P.  Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J. 2004;23:541-51.

Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell. 2003; 3:565-76.

Iso T, Chung G, Hamamori Y, Kedes L. HERP1 is a Cell Type-specific primary target of Notch. J. Biol. Chem. 2002, 277: 6598-6607.

Iso T, Vittorio Sartorelli, Coralie Poizat, Simona Iezzi, Hung-Yi Wu, Gene Chung, Larry Kedes, and Yasuo Hamamori. HERP,

A Novel Heterodimer Partner of HES/E(spl) in Notch Signaling. Mol. Cell. Biol. 2001; 21: 6080-6089.

Iso T, Vittorio Sartorelli, Gene Chung, Toshiaki Shichinohe, Larry Kedes, and Yasuo Hamamori. HERP, A New Primary Target of Notch Regulated by Ligand-binding. Mol. Cell. Biol. 2001; 21: 6071-6079.

Iso T, Arai M, Wada A, Kogure K, Suzuki T, Nagai R. Cardiac hypertrophy and expression of natriuretic peptides are enhanced by humoral factor(s) secondary to pressure overload. Am. J. Physiol. 1997; 273: H113-118.

Arai M, Yoguchi A, Iso T, Takahashi T, Imai S, Murata K, Suzuki T. Endothelin-1 and its binding sites are upregulated in pressure overloaded cardiac hypertrophy. Am. J. Physiol 1995; 268: H2084-2091.


総説

欧文

Kedes L, Kloner R, Kong K, Poizat C, Simkhovich B, Iso T, Hamamori Y. New cellular and molecular approaches for the treatment of cardiac disease. Semin Nephrol. 2004; 24: 437-40.
Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol. 2003; 194:237-55.
Iso T, Hamamori Y, Kedes L. Notch signaling in vascular development. Arterioscler Thromb Vasc Biol. 2003;23:543-53.

和文

磯達也、土井宏、倉林正彦 Notchと血管傷害 Molecular Medicine 2005; 42;336-341
磯達也 Notchシグナル系と血管形成 血管医学 2003; 4;597-605
磯達也 Notch-HERP経路による転写制御 分子心血管病 2002; 3: 711-718
磯達也、永井良三 心筋肥大・心室拡大の発生機序 Heart View 1997; 1: 30-35.
磯達也、永井良三 分子生物学よりみた心不全の治療 集中治療 1996; 8: 469-476.


国際学会発表

Tatsuya Iso, Hiroshi Doi, Masashi Arai, Masahiko Kurabayashi.
Notch-FABP4 pathway exerts anti-inflammatory effects in injured endothelium. Annual meeting of American Heart Association, Dalllas, 2005

Hiroshi Doi, Tatsuya Iso, Hiroko Sato, Toru Tanaka, Masashi Arai, Masahiko Kurabayashi.
HB-EGF inhibits TGF-b1 induced smooth muscle differentiation through the activation of Notch-HERP1 pathway. Annual meeting of American Heart Association, Dalllas, 2005

Hiroshi Doi, Tatsuya Iso, Hiroko Sato, Toru Tanaka, Masashi Arai, Masahiko Kurabayashi.
Notch ligand Jagged1 induces differentiation of vascular smooth muscle cells through RBP-Jk dependent mechanisms in mesenchymal cells. Annual meeting of American Heart Association, Dalllas, 2005

Tatsuya Iso, Toshitaka Maeno, Hiroshi Doi, Masashi Arai, Masahiko Kurabayashi.
Notch stimulation, but not gridlock homologue HERP1, induces arterial specific makers in venous cell line.
Annual meeting of American Heart Association, New Orleans, 2004

Hiroshi Doi, Tatsuya Iso, Ei-ichi Okamoto, Masashi Arai, Masahiko Kurabayashi.
HERP1, a target gene of Notch, maintains undifferentiated state of vascular smooth muscle cells by competing SRF co-activator, Myocardin.
Annual meeting of American Heart Association, New Orleans, 2004

Hiroshi Doi, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi.
Ventricular-specific HERP1 repressor regulates ventricular morphogenesis by suppressing expression of atrial-specific genes.
Annual meeting of American Heart Association, Orlando, 2003

Tatsuya Iso, Yasuo, Hamamori, Masahiko Kurabayashi, Larry Kedes.
HERPs are induced by Notch ligand stimulation in cardiovascular system.
Annual meeting of American Heart Association, Chicaco, 2002

Tatsuya Iso, Yasuo, Hamamori, Larry Kedes.
The HERP Repressors, Novel Partners for HES/hairy in Notch signaling.
Annual meeting of American Heart Association, New Orleans, 2000

Tatsuya Iso, Vittorio Sartorelli, Coralie Poizat, Tim Chen, Henry Sucov, Gene Chung, Hung-Yi Wu, Larry Kedes, Yasuo Hamamori.
The HERP repressors, Novel Partners for HES in Notch Signaling.
Asilomar meeting, Asilomar, 2000

Tatsuya Iso, Yasuo, Hamamori, Larry Kedes.
HERP1 and HERP2 expressed in cardiovascular system function as transcriptional repressors.
Annual meeting of American Heart Association, Atlanta, 1999

Tatsuya Iso, Masashi Arai, Tadashi Suzuki, Ryozo Nagai.
Humoral factor(s) secondary to pressure overload upregulate hypertrophic response in isografted heart.
Keystone Symposia, The molecular biology of the cardiovascular system, Keystone, 1996

Tatsuya Iso, Masashi Arai, Tadashi Suzuki, Ryozo Nagai.
Humoral and hemodynamic regulation of natriuretic peptides.
XV World congress of international society of heart research, Prague, 1995


賞罰

Fellowship from American Heart Association, Western State Affiliate, July 1999 to June 2001.
A Finalist of Young Investigator Award, American College of Cardiology in Anaheim, 2000.
第2回血管カンファレンス、研究助成受賞、平成14年2月
A finalist of Young Investigator Award, XIIth International Vascular Biology Meeting in Karuizawa, 2002
平成14年度分子循環器研究助成受賞、平成14年7月27日
第8回心血管病研究助成、優秀賞受賞、平成15年3月1日
第8回心血管病研究助成、最優秀賞受賞、平成16年3月6日
第2回日本心臓財団動脈硬化Update、最優秀賞受賞、平成16年9月4日


招待講演

磯達也、土井宏、倉林正彦:「Notchシグナルと血管平滑筋分化」、第5回学術集会Vascular Science Meeting(東京)、平成17年6月25日
磯達也、倉林正彦:「Notchシグナルと血管平滑筋分化」、生態調節研究所シンポジウム、平成18年3月16日


科学研究費

平成18-19年 基盤研究(C) 「Notchシグナルによる血管平滑筋細胞分化調節機構の解明」